RESEARCHARTICLE Plasmodiumvivax Reticulocyte Binding Proteins Are Key Targets of Naturally Acquired Immunity in Young Papua New GuineanChildren
نویسندگان
چکیده
1 Population Health and ImmunityDivision,Walter and Eliza Hall Institute of Medical Research,Melbourne, Australia, 2 Department of Medical Biology, University of Melbourne, Melbourne, Australia, 3 Infection and Immunity Division,Walter and Eliza Hall Institute of Medical Research,Melbourne, Australia, 4 Malaria Immuno-EpidemiologyUnit, PNG Institute of Medical Research,Madang, Papua New Guinea, 5 Malaria Parasites and Hosts Unit, Department of Parasites and Insect Vectors, Pasteur Institute, Paris, France, 6 Barcelona Institute of Global Health (ISGLOBAL), Barcelona, Spain
منابع مشابه
Plasmodium vivax Reticulocyte Binding Proteins Are Key Targets of Naturally Acquired Immunity in Young Papua New Guinean Children
BACKGROUND Major gaps in our understanding of Plasmodium vivax biology and the acquisition of immunity to this parasite hinder vaccine development. P. vivax merozoites exclusively invade reticulocytes, making parasite proteins that mediate reticulocyte binding and/or invasion potential key vaccine or drug targets. While protein interactions that mediate invasion are still poorly understood, the...
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Emerging evidence suggests that antibodies against merozoite proteins involved in Plasmodium falciparum invasion into the red blood cell (RBC) play an important role in clinical immunity to malaria. The protein family of parasite antigens known as P. falciparum reticulocyte binding protein-like homolog (PfRh) is required for RBC invasion. PfRh5 is the only member within the PfRh family that can...
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Abs targeting blood-stage Ags of Plasmodium falciparum are important in acquired immunity to malaria, but major targets remain unclear. The P. falciparum reticulocyte-binding homologs (PfRh) are key ligands used by merozoites during invasion of erythrocytes. PfRh2a and PfRh2b are functionally important members of this family and may be targets of protective immunity, but their potential role in...
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BACKGROUND Acquired antibodies are important in human immunity to malaria, but key targets remain largely unknown. Plasmodium falciparum reticulocyte-binding-homologue-4 (PfRh4) is important for invasion of human erythrocytes and may therefore be a target of protective immunity. METHODS IgG and IgG subclass-specific responses against different regions of PfRh4 were determined in a longitudina...
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BACKGROUND Plasmodium vivax is the most geographically widespread human malaria parasite. Cohort studies in Papua New Guinea have identified a rapid onset of immunity against vivax-malaria in children living in highly endemic areas. Although numerous P. vivax merozoite antigens are targets of naturally acquired antibodies, the role of many of these antibodies in protective immunity is yet unkno...
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